Is Collagen Powder High Histamine?

Collagen powder supplements are growing in popularity, and you might wonder whether collagen is high in histamine and whether It’s safe to take if you have histamine intolerance.

Is collagen powder high histamine? If so, is there a low-histamine collagen supplement?

If you have histamine intolerance or sensitivity, you know how important it is to choose foods that aren’t high in histamine and that don’t trigger histamine release. If you choose foods high in histamine, it increases your body’s histamine burden and can trigger histamine intolerance symptoms.

Choosing Low Histamine Foods is Challenging

Knowing what to eat and not eat with histamine intolerance is tricky, since not all foods are tested to see how much histamine they contain and whether they trigger histamine release. It would be easier to treat histamine intolerance if they did!

For some foods, you must judge how other people with histamine intolerance respond to the same foods, and also monitor your own body’s response to them by tracking your symptoms.

Since everyone has different levels of diamine oxidase, the enzyme that breaks histamine down, the response to different foods depends on your diet. That’s why it’s important to keep a food dairy and know what your individual tolerance to each food is.

Plus, there may be other compounds in the foods you eat, like other amines, that can trigger or worsen histamine intolerance symptoms. With collagen, things are tricker since makers of collagen powder don’t test their powder for histamine.

The amount of histamine may vary too, depending on how the manufacturer makes the collagen powder.

what is collagen powder 1

What is Collagen Powder?

Collagen is a structural protein that makes up connective tissue, the tissue that makes up various tissues in your body, including the cartilage inside your joints, tendons, the outer layer of blood vessels, and even bone.

Collagen also lies in the dermal layer of your skin, where it gives skin firmness and resistance to wrinkling. (5) Collagen also aids in wound healing. Based on its many functions, collagen can be very firm, as in bone tissue or less rigid, as in the collagen that surrounds blood vessels.

Collagen powder is a supplemental form of collagen. It comes in several forms. The most popular are collagen hydrolysate and gelatin. Collagen hydroxylate is hydrolyzed collagen, collagen broken down into amino acids that your body can more easily absorb.

Potential Health Benefits of Collagen

Collagen powder supplements are popular as small studies show supplementing with collagen may have health benefits, although its an area that needs more research.

As with most supplements, too many people jump on the bandwagon before there’s enough evidence that there’s a benefit.

Collagen is an important component of cartilage, the tissue inside your joints that keeps the bones within your joints from rubbing against each other. T

he most common health joint-related health problem is osteoarthritis, a degenerative form of arthritis caused by damage and breakdown of the cartilage inside joints.

What if you provide the joint with more collagen? The hope is that supplying more collagen to joints will help rebuild damaged cartilage and either improve the symptoms of osteoarthritis or slow its progression.

collagen powder may be helpful for osteoarthritis

The Science Behind Collagen Supplements for Osteoarthritis

Is there science to support the joint health benefits of collagen supplements? One review that looked at multiple randomized placebo-controlled trials relating to collagen supplements and osteoarthritis symptoms found that subjects who took a collagen supplement experienced improvements in two scales that measure arthritis symptoms.

Participants who took collagen reported less pain, stiffness, and improved function. (1)

Another study concluded that collagen hydrolysate and undenatured collagen may be of benefit for joints ravaged by osteoarthritis. (6) Many people are turning to collagen supplements because there are so few treatments for osteoarthritis.

Collagen for Skin Aging

Another reason collagen supplements are increasing in popularity is as a nutraceutical for skin aging. Collagen is a structural protein in the dermis, the layer just beneath the epidermis, in the skin. It’s collagen that gives your skin support and resistance to wrinkling and laxity.

Some studies show supplemental collagen improves some aspects of skin aging. For example, a double-blind, placebo-controlled, randomized trial of 120 individuals found benefits. (2) The subjects consumed a collagen supplement or a place for 90 days.

The results? Those who consumed the collagen supplement experienced improvements in skin elasticity. When skin is more elastic, it’s firmer and appears more youthful. Plus, participants who took the collagen supplement showed improvements in skin texture.

So, people are using collagen powder supplements mainly for joint issues, like osteoarthritis, and to support skin health and healthy skin aging. However, it’s an area that still needs more research, as the studies showing benefits are small. Yet they are randomized controlled trials, the highest quality type of study.

collagen powder for aging skin

Is Collagen Powder High Histamine?

Despite the potential health benefits of collagen for osteoarthritis and skin aging, collagen powder and collagen supplements worsen histamine intolerance symptoms in some people.

There are reports of histamine intolerance sufferers who tried collagen powder or bone broth, another source of collagen, and claim their symptoms worsened.

Among patients I’ve talked to, the most common symptom mentioned was diarrhea. It’s impossible to say whether it was the collagen powder or some other factor that triggered the diarrhea, but it went away once they stopped the collagen supplement.

Taking a collagen powder has the potential to unleash a number of histamine intolerance symptoms if you have very low diamine oxidase level or you’re sensitive to the amines in collagen powder or some other component.

A few people with histamine intolerance experienced a constant headache after they began a collagen supplement Since diarrhea and headache are non-specific symptoms that have many causes, it’s hard to say whether the collagen powder was responsible for the symptoms.

Still, it’s a sign that you should approach supplemental collagen with caution.

Are There Low-Histamine Collagen Supplements?

If you want the potential benefits that collagen offers for joint or skin health, but have histamine intolerance, you might wonder if there are low-histamine collagen supplements safe to take?

Since collagen makers don’t test their products for histamine or other biogenic amines, you don’t know the histamine content of a given collagen supplement.

So, there’s no confirmed low-histamine collagen supplement you can count on not to trigger histamine intolerance.

Bone Broth is Rich in Collagen Too

It’s a similar story with bone broth. When manufacturers make bone broth, they add animal bones and what’s in the bones of animals? Yep! Collagen. So, approach bone broth with caution too. It’s possible that during the making of bone broth, histamine enters the broth from the animal flesh and bones used to make it.

The amount of histamine that enters the broth would increase when the bones are simmered longer. So, bone broth would contain varying amounts of histamine based on how long you simmer the bones.

Because everyone is a little different, I’ve talked to people with histamine intolerance who have no problems with collagen powder or bone broth. If you have osteoarthritis and are determined to try it, keep a food diary, and track your symptoms closely.

If you have histamine intolerance, it’s best to avoid collagen supplements, unless you have a strong reason to take one or your doctor recommends it.

And even then, approach them with caution. Many people are taking collagen now and drinking bone broth because it’s trendy.

bone broth is high in histamine

Other Concerns about Collagen Powder if You Have Histamine Intolerance

Beyond the histamine content of collagen powder, there are other reasons to be cautious about taking supplemental collagen. Independent testing of some collagen powders shows they contain harmful impurities like heavy metals.

When you take a supplement, you have no assurance it contains what’s on the label. It’s best to select supplements independently tested by a third party for purity.

According to Harvard Health, bone broth also poses heavy metal risk. (3) A study showed that bone broth contains harmful heavy metals like lead and cadmium, and only contains small quantities of minerals, like calcium and magnesium. (4)

It’s not surprising that bone broth contains lead, since animals who take in lead from the environment store it in their bones. Animal bones can also store other toxic metals.

When you consider the fact that bone broth also contains histamine, it’s a no-go for most people with histamine intolerance.

Avoid Collagen Supplements

Is collagen powder high histamine? One thing most people with histamine intolerance learn early is that foods that are healthy for other people can cause reactions if you have histamine intolerance. For some people, that includes collagen supplements and foods high in collagen, like bone broth.

Anecdotally, not everyone tolerates collagen supplements well, and there aren’t known low-histamine collagen supplements out there.


  1. García-Coronado JM, Martínez-Olvera L, Elizondo-Omaña RE, Acosta-Olivo CA, Vilchez-Cavazos F, Simental-Mendía LE, Simental-Mendía M. Effect of collagen supplementation on osteoarthritis symptoms: a meta-analysis of randomized placebo-controlled trials. Int Orthop. 2019 Mar;43(3):531-538. doi: 10.1007/s00264-018-4211-5. Epub 2018 Oct 27. PMID: 30368550.
  2. Genovese L, Corbo A, Sibilla S. An Insight into the Changes in Skin Texture and Properties following Dietary Intervention with a Nutricosmeceutical Containing a Blend of Collagen Bioactive Peptides and Antioxidants. Skin Pharmacol Physiol. 2017;30(3):146-158. doi: 10.1159/000464470. Epub 2017 May 20. PMID: 28528342.
  3. “Collagen | The Nutrition Source | Harvard T.H. Chan School ….”
  4. Hsu DJ, Lee CW, Tsai WC, Chien YC. Essential and toxic metals in animal bone broths. Food & nutrition research. 2017 Jan 1;61(1):1347478.
  5. Schönborn K, Willenborg S, Schulz JN, Imhof T, Eming SA, Quondamatteo F, Brinckmann J, Niehoff A, Paulsson M, Koch M, Eckes B, Krieg T. Role of collagen XII in skin homeostasis and repair. Matrix Biol. 2020 Dec;94:57-76. doi: 10.1016/j.matbio.2020.08.002. Epub 2020 Sep 2. PMID: 32890632.
  6. Honvo G, Lengelé L, Charles A, Reginster JY, Bruyère O. Role of Collagen Derivatives in Osteoarthritis and Cartilage Repair: A Systematic Scoping Review With Evidence Mapping. Rheumatol Ther. 2020 Dec;7(4):703-740. doi: 10.1007/s40744-020-00240-5. Epub 2020 Oct 17. PMID: 33068290; PMCID: PMC7695755.

Hi! I'm Dr. Kristie Leong M.D. M.S. I graduated from Virginia Commonwealth University and have a deep interest and passion for histamine intolerance. My journey includes a comprehensive Kindle ebook on Histamine Intolerance and its dietary management.With a Masters in Clinical Pathology, my knowledge of immunology adds a robust scientific foundation to my expertise. I wholeheartedly believe in the power of lifestyle and prevention in healthcare. Let's work together to manage histamine intolerance through practical dietary and lifestyle choices. :-)