Are Grapes Low Histamine?

Are grapes low histamine? Living with histamine intolerance can be a challenge. When your body can’t efficiently break down histamine, it builds up in your bloodstream, leading to a host of unpleasant symptoms like headaches, hives, and digestive issues.

Figuring out what to eat and avoid becomes a daily puzzle. But fear not! We’ll help you unravel the mysteries of histamine and navigate the culinary minefield.

Understanding Histamine Intolerance and its Symptoms

Histamine intolerance occurs when your body is unable to break down histamine efficiently, leading to an excess of this chemical in your bloodstream.(2) Histamine is a chemical that is naturally produced in the body and found in certain foods. When histamine levels become too high due to an inability to break it down, this can lead to histamine intolerance.

Scientists don’t fully understand the cause of histamine intolerance yet, but some possible factors include genetics, certain medications, gut health issues like leaky gut syndrome (3) or small intestinal bacterial overgrowth (SIBO), and enzyme deficiencies.

The symptoms of histamine are variable, with some people experiencing more digestive symptoms and others developing frustrating problems, like headaches, brain fog, itching, or anxiety. (4) The symptoms can vary from day to day, based on your diet, stress level, etc.

That’s why monitoring your diet is so important. In this article, we’ll take a closer look at the histamine content in grapes and whether they are suitable for those with histamine intolerance. We’ll also explore other low-histamine fruits that you can try if grapes don’t work for you.

By the end of this article, you’ll have all the information you need to make informed decisions about your diet and manage your histamine intolerance effectively.

mast cell releasing histamine
Mast cell releasing histamine.

Are Grapes Low Histamine?

Grapes are a popular fruit that many people enjoy as a snack or as part of their meals. However, if you have histamine intolerance, you may be concerned about whether they will trigger symptoms.

Interestingly, some individuals with histamine intolerance have reported experiencing symptoms after consuming grapes. A number of histamine intolerance sufferers I’ve worked with over the years believe that grapes aggravate their histamine intolerance symptoms.

What’s interesting about this is that grapes aren’t inherently high in histamine. However, the level of histamine in grapes can vary depending on the variety, growing conditions, harvesting techniques, and grape derivatives used in culinary applications.

A Variety of Factors Affect the Histamine Content of Grapes

Red and purple grape varieties tend to have a higher histamine content than green or white varieties. (5) Additionally, grapes harvested late or allowed to overripen may have higher levels of histamine. As mentioned, grape derivatives such as wine (6) and vinegar may also contain higher levels of histamine due to the fermentation process.

Despite this variability, some individuals with histamine intolerance can consume grapes without issue. So, they aren’t a food that is a “must avoid,” like fermented foods that aggravate histamine intolerance symptoms for everyone.

But some individuals do report symptoms after consuming grapes, others may not be affected at all. It’s important for those with histamine intolerance to keep track of which foods trigger their symptoms and avoid them accordingly.

There is also evidence that grapes are a histamine liberator, meaning they trigger the release of histamine from mast cells. (8) That’s why it’s important to approach grapes with caution and in small amounts.

Effects of Grapes on Histamine Intolerance

It’s important to understand how certain foods can impact our bodies and cause discomfort for those with histamine intolerance. That’s why exploring the effects of different fruits and vegetables is crucial.

When it comes to grapes, they have been found to be low in histamine content compared to other fruits like citrus or berries. However, there are different grape varieties and cooking methods that can affect their potential benefits for those with histamine intolerance.

Plus, products made from grapes, like wine, may contain substantial quantities of histamine and other biogenic amines. (1, 6)

products made from grapes can be high histamine

Cooking methods like roasting or grilling foods (7) can also intensify the flavor of grapes and potentially increase their histamine content. Additionally, seasonal availability may play a role in the overall freshness of grapes and their potential impact on histamine intolerance symptoms.

Riper grapes, because they are exposed to more bacteria, will likely be higher in histamine than younger ones that haven’t had time to ripen and produce histamine from bacterial fermentation.

Other Low Histamine Fruits to Try

If you’re looking for some tasty and safe fruit options to add to your low-histamine diet, try bananas, mangoes, blueberries, apples and cantaloupe. These fruits are all low in histamine levels and can provide alternative options for those who may be sensitive to grapes or simply want to switch up their fruit choices.

In addition to being low in histamine, these fruits also offer various nutritional benefits. Bananas are a good source of potassium, fiber, and vitamin B6, while mangoes contain high levels of vitamin C and antioxidants.

Cantaloupes are rich in vitamins A and C as well as beta-carotene. Each fruit also has its own unique flavor profile that can be enjoyed on their own or incorporated into recipes such as smoothies or salads.

Keep in mind that seasonal availability may vary depending on where you live, so it’s always a good idea to check your local grocery store or farmer’s market for the freshest options.

Experiment with different preparation methods such as grilling or freezing for added variety in your diet. With these alternative fruit option available, you can still enjoy flavorful fruits.

Tips for Managing Histamine Intolerance with Diet

Managing histamine intolerance through diet can be a challenge, but with some simple adjustments and awareness, it’s possible to find relief from symptoms and still enjoy a variety of delicious foods. It just takes knowledge and planning.

grapes in modest quantities may be suitable for a low histamine diet

Are Grapes Low Histamine?

When it comes to grapes, they do contain histamine but are considered low in histamine compared to other fruits. This means that individuals with histamine intolerance may be able to tolerate grapes in moderation without experiencing adverse effects.

However, it’s important to note that everyone’s tolerance levels may vary, and it’s best to listen to your body and work with a healthcare professional to determine what foods work best for you. Also, find out whether cranberries are low histamine.

Remember that while diet can play a role in managing histamine intolerance symptoms, it’s not a cure-all solution. It’s also important to address other factors like stress management and environmental triggers.

Managing histamine intolerance through diet can be a challenge, but with some simple adjustments and awareness, it’s possible to find relief from symptoms and still enjoy a variety of delicious foods.

With the right combination of strategies tailored specifically for you by a healthcare professional, living with histamine intolerance can become more manageable.

Key Takeaways

  • Grapes have relatively low levels of histamine compared to other fruits like citrus or strawberries. However, they may be histamine liberators.
  • Cooking methods that intensify the flavor of grapes, such as roasting or grilling, may potentially increase their histamine content.
  • Red and purple grapes, particularly ripe ones, may contain more histamine than white grapes.
  • Tracking symptoms and keeping a food diary can help identify triggers and make it easier to stick to a low-histamine diet over time.


  1. “Amghouz, Z.. Biogenic amines in wine: a review”. Ifst.Onlinelibrary.Wiley.Com, 2023, Accessed 5 Jun 2023.
  2. Histamine and histamine intolerance. (2023). Retrieved 9 June 2023, from
  3. Schnedl WJ, Enko D. Histamine Intolerance Originates in the Gut. Nutrients. 2021 Apr 12;13(4):1262. doi: 10.3390/nu13041262. PMID: 33921522; PMCID: PMC8069563.
  4. “Histamine Intolerance: Causes, Symptoms, and Diagnosis – Healthline.”
  5. “The Different Types Of Wine Grapes And Their Histamine Levels.” 23 Oct. 2022,
  6. Smit AY, Engelbrecht L, du Toit M. Managing your wine fermentation to reduce the risk of biogenic amine formation. Front Microbiol. 2012 Mar 13;3:76. doi: 10.3389/fmicb.2012.00076. PMID: 22419915; PMCID: PMC3301445.
  7. Chung BY, Park SY, Byun YS, Son JH, Choi YW, Cho YS, Kim HO, Park CW. Effect of Different Cooking Methods on Histamine Levels in Selected Foods. Ann Dermatol. 2017 Dec;29(6):706-714. doi: 10.5021/ad.2017.29.6.706. Epub 2017 Oct 30. PMID: 29200758; PMCID: PMC5705351.
  8. Son JH, Chung BY, Kim HO, Park CW. A Histamine-Free Diet Is Helpful for Treatment of Adult Patients with Chronic Spontaneous Urticaria. Ann Dermatol. 2018 Apr;30(2):164-172. doi: 10.5021/ad.2018.30.2.164. Epub 2018 Feb 21. PMID: 29606813; PMCID: PMC5839887.

Hi! I'm Dr. Kristie Leong M.D. M.S. I graduated from Virginia Commonwealth University and have a deep interest and passion for histamine intolerance. My journey includes a comprehensive Kindle ebook on Histamine Intolerance and its dietary management.With a Masters in Clinical Pathology, my knowledge of immunology adds a robust scientific foundation to my expertise. I wholeheartedly believe in the power of lifestyle and prevention in healthcare. Let's work together to manage histamine intolerance through practical dietary and lifestyle choices. :-)